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In a new study in animal models, researchers demonstrate how genetic variability in key risk genes leads to different brain development patterns. Studying the brains of people with autism is challenging, since there are fewer resources to study. However, scientists get creative and collaborative and re-analyze datasets previously published to look at different research questions. That’s what happened this week in a collaboration between Brown University and UCLA, showing that as the activity of genes which controls the synapse goes down, so do genes affecting mitochondrial function. Another brain tissue study showed that the stress of the endoplasmic reticulum, which is associated with the mitochondria, may be elevated. Not all research data can be re-purposed again, which is why it is so important to study the brains of people with autism. If you would like to learn more, go to www.takesbrains.org/signup
https://www.ncbi.nlm.nih.gov/pubmed/29859039
https://www.ncbi.nlm.nih.gov/pubmed/29761862
https://www.ncbi.nlm.nih.gov/pubmed/29901787
https://www.ncbi.nlm.nih.gov/pubmed/29926239