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More about the environmental influences in autism

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New research points to a previously understudied but fascinating mechanism by which environmental factors may lead to autism: it’s called the “GABA/glutamate switch” which is a critical period in development when certain cells turn from turning on cell activity to turning them off. These environmental factors may delay this process leading to long term effects on the developing brain consistent with autism. While this data on the mechanism is brand new, the topic of the environment in autism was inspired by a recent effort at NIEHS which is developing an interactive database for people to access information about what environmental exposures have been studied and how in autism.

https://www.niehs.nih.gov/news/events/aware

https://www.pnas.org/doi/epub/10.1073/pnas.2406928121

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A 2022 Day of Learning Quickie

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This year’s Day of Learning was a huge success, with topics ranging from biological sex differences to mobile technologies all the way to the importance and documented value of leisure activities in people on the spectrum. the speakers included a discussion of the IACC, sex differences, the value of prevalence data, mobile technologies, leisure activities, and a recognition of two advocates who made or make a difference in families: Samantha Els and Suzanne Wright. Listen to this week’s podcast for a quickie, but don’t let it prevent you from watching the longer videos, a link to which can be found below

www.babynavigator.com

www.autismnavigator.com

Day of Learning
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New ways to solve old problems

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This week’s podcast focuses on innovative methodologies to understand how to reach black families, understand why and when autistic people prefer not to look at faces and how interventions can improve conversation and social communication. They use culturally and racially matched mentors, old home video tapes (keep taking those!) and machine learning to look not just at novel methods but novel ways of studying a particular outcome.

https://pubmed.ncbi.nlm.nih.gov/35232271/

https://pubmed.ncbi.nlm.nih.gov/35228613/

https://pubmed.ncbi.nlm.nih.gov/35229983/

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Talk talk talk…..it may make a difference to your infant

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Children and infants who later go on to have an autism diagnosis show impairments in communication. Is there anything that parents can do? Yes! Talk. Talk in complicated sentences. Talk responsively and keep it up. This isn’t always an inherent skill, it’s learned, and in this podcast we talk about the biological basis of why infants with ASD are more sensitive to verbal input, how hyposensory features are involved and what you can do to improve your verbal responsiveness that needs to be different for your child with ASD

https://pubmed.ncbi.nlm.nih.gov/34128355/

https://pubmed.ncbi.nlm.nih.gov/34185234/

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Parents describe the “best things” about their kids with ASD

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Parents may see challenges in their kids with ASD, but they also know what is great about them and the unique gifts they bring to the world. Now, researchers from Canada have inventoried and categorized these list of great qualities in a large study of children from 3-10 years of age. These “best things” identified and counted across ages should also be used when planning how to transition kids with ASD from EI or preschool into kindergarten. Another study included this week from Curtin University in Australia describes how parents see this process becoming a lot easier.

https://pubmed.ncbi.nlm.nih.gov/33532881/

https://pubmed.ncbi.nlm.nih.gov/33520781/

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Which came first, ASD or sleep problems?

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People with autism have lots of problems, and sleep is one of them. This week’s podcast explores when these problems begin, which brain areas are involved, and how autism contributes to, or suffers from, lack of sleep. Does sleep make ASD worse or are ASD symptoms causing a sleep problems? It’s not a one way street, and the neurons that go to the wrong places at the wrong times which cause ASD, may also be contributing to lack of good sleep. References below:

https://pubmed.ncbi.nlm.nih.gov/33207724/

https://pubmed.ncbi.nlm.nih.gov/33184732/

https://pubmed.ncbi.nlm.nih.gov/32375538/

https://pubmed.ncbi.nlm.nih.gov/32140983/

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Age of parents and ASD. It’s complicated.

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Questions have loomed around the finding of an increased risk of parents having a child with ASD if they are under 20 or over 35. Of course not every parent who is really young or older will have a child on the spectrum and plenty of those between those ages also have children on the spectrum. Risk factors for ASD are not absolute, they are nuanced and work with other genetic and environmental factors. This week, Kristin Lyall from the AJ Drexel Autism Institute found that those with a strong genetic influence were not as sensitive to factors like parental age. This goes to show, yet again, that it isn’t about ONE risk factor, it’s about dozens working together. And for those 30 year old parents who had a child with autism – see, not every research finding applies to you directly.

https://www.ncbi.nlm.nih.gov/pubmed/32314879

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521130/

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News new families can use, thank you to the BSRC

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This week an important study was released that provides information that parents can use – particularly parents with a child with autism and another on the way or who is an infant.  This of course comes from the Baby Siblings Research Consortium and makes particular observations about families with 2 or more affected children vs 1 affected child.  They have different rates of autism outcomes and trajectories of behaviors that parents and doctors should be aware of.  In addition a new meta analysis of vitamin supplementation shows that while moderate doses of vitamins may not be harmful, they may not also be helpful.  In other words, talk to your doctor about a nutritional plan and assessment, and save your money for things that are known to work.

https://www.ncbi.nlm.nih.gov/pubmed/31589284

https://www.ncbi.nlm.nih.gov/pubmed/31586029

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In autism, what does protection mean?

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Some autistics are offended by the word “protection” when it comes to autism, but in addition to things increasing the probability of a diagnosis, some things reduce the probability?  This week’s podcast explores the female protective effect as well as a new study from the BASIS study in the UK looking at early regulatory function as a protective factor in ASD and ADHD traits.

https://www.ncbi.nlm.nih.gov/pubmed/31347307

https://www.ncbi.nlm.nih.gov/pubmed/31351456