Autism and disorders of aging

We have talked already about the link between autism and dementia, however a lesser known association is the one between autism and another disorder of aging: Parkinson’s Disease. A recent presentation at INSAR revealed what is known about the relationship, why they are related, what causes the association and what people with autism can do to possibly mitigate the onset of dementia and Parkinson’s Disease. Thank you to Dr. Blair Braden and Samantha Harker and Manuela Velez Galindo from the Autism and Brain Aging Lab at Arizona State University (@autismbrainaginglab @asuresearch) for joining this podcast and explaining the findings so far and what they mean for individuals and families with autism.

https://pubmed.ncbi.nlm.nih.gov/25911091

Autism and diseases of the aging brain

As the autistic brain ages, is it more vulnerable to other brain disorders? Recent scientific discoveries in Parkinson’s Disease and Alzheimer’s Disease show that there may be an underlying mechanism between these diseases and autism. However diagnosing someone with autism with an additional brain disorder, especially dementia, can be difficult. This week’s podcast covers the increased risk of Parkinson’s Disease in autism, as well as provides advice from a group of experts on how to diagnose an autistic person with dementia, since there may be overlap in features.

https://jamanetwork.com/journals/jamaneurology/fullarticle/2834684?guestAccessKey=4961ce0b-24e8-412a-b1cc-35fc5826fbe1&utm_source=fbpage&utm_medium=social_jamaneur&utm_term=17468134139&utm_campaign=article_alert&linkId=837634061

https://pmc.ncbi.nlm.nih.gov/articles/PMC12144002

The risk of dementia in older adults

https://pubmed.ncbi.nlm.nih.gov/34378867/

There have been several small, or small-ish, studies looking at the link between dementia and autism or ID. However, recently, the largest medical record study of 500k people, 12k of which were autistic and 26k were autistic and had ID, examining early onset dementia was published. Those with ASD had a 1.9 increased risk for dementia and it was even higher for those with ASD + ID. Why? Is it psychological or biological or both? Researchers at the AJ Drexel Autism Institute investigate.