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What can understanding autistic transgender individuals tell us about sex differences in ASD?

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Happy Pride! In honor of June, this week’s podcast focuses on the specific needs of those who are transgender or sexually diverse and also autistic. What is the prevalence of autism in those who are transgender and what is the prevalence of being transgender in those who are autistic? New research has emerged which shows that mental and physical health problems are more prevalent in those with an autism diagnosis and transgender compared to those who are not autistic and transgender. What can we learn about sex differences in diagnoses of males and females through studying those who are also transgender? Also, Laura Graham Holmes who authored one of the studies comments on the importance of her research.

Click to access 10.1177_07067437261442432.pdf

https://onlinelibrary.wiley.com/doi/10.1002/aur.70235

https://pubmed.ncbi.nlm.nih.gov/41614651

https://www.nature.com/articles/s41467-020-17794-1

https://pubmed.ncbi.nlm.nih.gov/41533668

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Autism and disorders of aging

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We have talked already about the link between autism and dementia, however a lesser known association is the one between autism and another disorder of aging: Parkinson’s Disease. A recent presentation at INSAR revealed what is known about the relationship, why they are related, what causes the association and what people with autism can do to possibly mitigate the onset of dementia and Parkinson’s Disease. Thank you to Dr. Blair Braden and Samantha Harker and Manuela Velez Galindo from the Autism and Brain Aging Lab at Arizona State University (@autismbrainaginglab @asuresearch) for joining this podcast and explaining the findings so far and what they mean for individuals and families with autism.

https://pubmed.ncbi.nlm.nih.gov/25911091

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Antidepressants do not cause autism

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In all the recent hype on the “overprescribing” of psychiatric medications, there is a circulating rumor antidepressant use in the mother during pregnancy has could be linked to an autism diagnosis in the child. Thankfully, there is research on this topic, and the results are clear: antidepressant exposure during pregnancy does not cause autism in children. Where would this idea come from? Early studies did show a weak link, but the association arises because there is a genetic link between having a psychiatric disorder like anxiety and stress and autism. Don’t stop taking your meds unless you discuss it with your doctor. References below:

https://pubmed.ncbi.nlm.nih.gov/42134364

https://pubmed.ncbi.nlm.nih.gov/42088678/

https://pubmed.ncbi.nlm.nih.gov/42168841/