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Catching up with CANDID

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In part 2 of the GI series in ASD, a new paper in the Journal of Nutrition and Gastroenterology describing the www.candidgi.com meeting is described. While sometimes doctors may be know-it-alls, sometimes they do not know-it-all and need experts to advise them, especially when they encounter individuals who may be hard to diagnose and treat. Those with intellectual disability and who are non-speaking may pose specific challenges in diagnosing medical issues, including GI problems. This podcast describes the symptoms that may be obvious, some that are not so obvious, and what GI doctors need to do to help these families.

https://pubmed.ncbi.nlm.nih.gov/37323113

www.candidgi.com

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Mysteries of the Microbiome

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In the first of a two-part series on digestive health in ASD, Mia Kotikovski summarizes scientific information about what the complicated microbiome is, how it influences physical and psychiatric health, if it is altered in autism, and what causes it to be different in ASD.

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Let’s talk about poop

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This week we discuss the CANDID meeting: Consortium for Autism, Neurodevelopmental Disorders and Digestive Diseases, what was shared, what was learned, and where doctors and researchers need to do more. They included the link between the brain-gut connection, challenges in diagnosis, ongoing studies, potential solutions, and what pediatric gastroenterologists need to know about helping families with NDD’s and GI issues. Go to www.candidgi.com to watch the full set of presentations by scientists, families, and advocates.

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What’s in the medicine jar?

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This week is a pharmacopeia of inflation. The #ASFpodcast talks debilitating gastrointestinal issues and new efforts to understand and treat them (including the CANDID meeting www.candidgi.com), a new method to understand adverse events in those that cannot report them on their own, and new news on Celexa, which is used to treat anxiety.

www.candidgi.com

info@candidgi.com

https://www.theautismstudy.com

https://pubmed.ncbi.nlm.nih.gov/35165451/

https://pubmed.ncbi.nlm.nih.gov/35501967/

https://pubmed.ncbi.nlm.nih.gov/34652075/

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You asked, we answered: what is the connection between the ‘gut’ and the brain?

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On this week’s podcast, we answer your question: “what’s the evidence of a gut-brain connection”? We can’t answer that question without starting off with a description of the microbiome. The microbiome is the colony of organisms in your gastrointestinal system that is showing increasing evidence of influencing brain function. We asked three experts: Calliope Holingue from JHSPH, Helen Vuong from UCLA and Stewart Campbell of Axial Therapeutics what is happening in research around the microbiome in autism, and what therapeutics are being developed to help those with GI issues and ASD.

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More on why intellectual disability matters.

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There have been more than a few podcasts lately about why intellectual abilities (or disability) are important in understanding ASD. It will probably be a theme in the end of year summary. This week, intellectual ability affects risk of dying from COVID and how anxiety is measured. Some studies show that increasing cognitive ability increases chances of having anxiety, although, because it is not always measured appropriately in those with intellectual disability, this linear relationship may not hold. However, while it is important in anxiety and COVID, it may have less to do with how pain is expressed. Podcast links below:

If you want to register for the December 9thwebinar about the COVID Vaccine:  

https://www.chop.edu/centers-programs/vaccine-update/vaccine-webinar-series

Developmental disorders top the medical conditions that heighten the risk of dying from Covid-19

https://pubmed.ncbi.nlm.nih.gov/33198481/

https://pubmed.ncbi.nlm.nih.gov/33175317/

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Scientists know in their gut how the GI symptoms are linked to autism

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People with autism have higher levels of GI problems then people without a diagnosis, and the microbiome is associated with GI function, so is the microbiome linked to autism?  Some studies say yes, but this week studies in China look at non-caucasian people eating different diet.  Do the differences still hold?  Also, while GI  symptoms have been studied in relation to core autism features, they have not yet been linked to psychiatric issues like anxiety, ADHD, and aggression.  Until now.  This week’s podcast features three new studies looking GI issues and the causes of those issues, in kids with autism.

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204460/

https://www.ncbi.nlm.nih.gov/pubmed/30394313

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143520/