Two studies of importance came out this week. The first looked at the interactive effects of genetic mutations called copy number variations and air pollution. Previously, ozone was not listed in the factors in air pollution that increased risk for autism. But combine it with copy number variations – now the two together dramatically increase risk. Ozone levels are something that can be reduced through legislation. Second, the role of internet addiction is generally not acknowledged or appreciated, but a recent study demonstrated that people with autism show triple the rate of internet addiction compared to those without autism. This is something that psychiatrists and psychologists should know about when they think about treatments and comorbidities of people with ASD.
Overall, the scientific research examining the efficacy of oxytocin treatment in autism spectrum disorder has been mixed. On a previous podcast, studies in the way the oxytocin receptor was turned on and off were explained which may account for variability in treatment response. This week, two studies in Japan show that specific mutations in the oxytocin receptor product predict who will respond to oxytocin treatment and who will not. Therefore, the oxytocin story is one of the first examples of using genetic findings to push better treatment on an individual level, otherwise known as precision medicine.