The potential role of epigenetics in the sex differences in autism

On Tuesday November 15th, Tracy Bale from University of Pennsylvania provided an insightful analysis of sex differences in behavioral, physiological and molecular outcomes following prenatal stress.  She outlined the potential epigenetic markers that may lead to resilience in female offspring which has direct implications for autism.  However, prior to Dr. Bale’s presentation, Donna Werling from UCSF briefly outlined the genetic and behavioral data so far about females with autism and why there is a 4:1 ratio in males to females getting a diagnosis.  This webinar is part of the Environmental Epigenetics of Autism Webinar Series co-organized by Autism Science Foundation, Autism Speaks and the Escher Family Fund for Autism.

Sex differences in autism symptoms, and anxiety and depression too

Dr. Katherine Gotham from Vanderbilt University graciously joins us to talk about changes in anxiety and depression in females and males with autism across time and why these findings have consequences for diagnosis and treatment of not just autism but co-occuring conditions.  Also, males and females with autism have differences in brain structure that may explain some symptoms of autism.  You may have read the story in the media but hear the breakdown on this week’s podcast.

Molecular Autism special issue on gender differences

Study on the amazing brains of females with autism highlighted in the special issue of Molecular Autism focusing on the sex difference. In addition, recommendations for research by researchers is outlined.